Diane M Simeone Selected Research

Pancreatic Neoplasms (Pancreatic Cancer)

10/2023	Targeting pancreatic cancer metabolic dependencies through glutamine antagonism.
1/2023	Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance.
1/2022	Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts.
1/2021	A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment.
1/2021	Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.
1/2020	Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
1/2019	A Phase I/II Open-Label Multicenter Single-Arm Study of FABLOx (Metronomic 5-Fluorouracil Plus nab-Paclitaxel, Bevacizumab, Leucovorin, and Oxaliplatin) in Patients with Metastatic Pancreatic Cancer.
12/2018	Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers.
1/2018	Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.
10/2017	Definitive Chemoradiation With Full-dose Gemcitabine for Unresectable Pancreatic Cancer: Efficacy of Involved-Field Radiotherapy.

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Diane M Simeone Research Topics

Disease

83	Neoplasms (Cancer) 10/2023 - 05/2003
73	Pancreatic Neoplasms (Pancreatic Cancer) 10/2023 - 08/2004
31	Adenocarcinoma 10/2023 - 08/2004
16	Chronic Pancreatitis 01/2016 - 08/2004
10	Neoplasm Metastasis (Metastasis) 01/2023 - 03/2007
7	Carcinogenesis 01/2023 - 03/2008
6	Cysts 11/2021 - 01/2011
5	Pancreatic Cyst 11/2021 - 05/2012
5	Circulating Neoplastic Cells 12/2019 - 12/2014
5	Pancreatitis 01/2018 - 06/2008
3	Hepatocellular Carcinoma (Hepatoma) 01/2023 - 12/2014
3	Urinary Bladder Neoplasms (Bladder Cancer) 08/2022 - 12/2015
3	Neuroendocrine Tumors (Neuroendocrine Tumor) 12/2014 - 02/2007
2	Pain (Aches) 01/2020 - 01/2016
2	Hypoxia (Hypoxemia) 01/2018 - 08/2004
2	Breast Neoplasms (Breast Cancer) 03/2013 - 10/2012
2	Neoplasms, Cystic, Mucinous, and Serous 01/2011 - 05/2010
2	Disease Progression 01/2009 - 12/2008
1	Bites and Stings (Sting) 01/2023
1	Cholangiocarcinoma 01/2023
1	Fibrosis (Cirrhosis) 01/2023
1	Fatigue 01/2020
1	Genomic Instability 07/2019
1	Ovarian Neoplasms (Ovarian Cancer) 10/2018

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2004
27	Biomarkers (Surrogate Marker)IBA 01/2020 - 09/2006
15	Gemcitabine FDA Link 01/2019 - 10/2007
11	Glycoproteins (Glycoprotein)IBA 01/2015 - 07/2006
6	RNA (Ribonucleic Acid)IBA 07/2023 - 03/2013
6	Epithelial Cell Adhesion MoleculeIBA 01/2023 - 02/2007
6	Polysaccharides (Glycans)IBA 01/2016 - 07/2006
6	LectinsIBA 08/2011 - 07/2006
4	ProteomeIBA 01/2022 - 07/2010
4	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2019 - 10/2007
4	AutoantibodiesIBA 06/2009 - 08/2004
3	LigandsIBA 01/2023 - 08/2013
3	EnzymesIBA 01/2021 - 10/2012
3	DNA (Deoxyribonucleic Acid)IBA 07/2019 - 03/2014
3	CytokinesIBA 01/2016 - 09/2012
3	HaptoglobinsIBA 04/2014 - 05/2007
3	Wheat Germ AgglutininsIBA 10/2013 - 07/2006
3	AntibodiesIBA 10/2013 - 08/2004
3	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA 06/2012 - 06/2010
3	Neoplasm Antigens (Tumor Antigens)IBA 06/2009 - 08/2004
2	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 08/2004
2	Carcinoembryonic AntigenIBA 11/2021 - 05/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 07/2015
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2020 - 01/2016
2	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 01/2016
2	130-nm albumin-bound paclitaxelIBA 01/2019 - 01/2016
2	Leucovorin (Folinic Acid)FDA Link 01/2019 - 01/2016
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2018 - 10/2018
2	trametinibIBA 12/2018 - 10/2018
2	Phosphotransferases (Kinase)IBA 10/2018 - 03/2013
2	LuciferasesIBA 01/2018 - 06/2010
2	graphene oxideIBA 06/2016 - 10/2013
2	OligosaccharidesIBA 01/2016 - 03/2007
2	MicroRNAs (MicroRNA)IBA 12/2015 - 03/2012
2	UbiquitinIBA 11/2015 - 09/2012
2	Peptides (Polypeptides)IBA 04/2015 - 12/2014
2	GlycopeptidesIBA 04/2015 - 07/2006
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 12/2014 - 12/2013
2	Small Interfering RNA (siRNA)IBA 01/2014 - 03/2007
2	Blood Proteins (Serum Proteins)IBA 08/2011 - 01/2009
2	CarbohydratesIBA 01/2011 - 07/2006
2	AgglutininsIBA 05/2010 - 07/2006
2	Collodion (Nitrocellulose)IBA 01/2010 - 06/2009
2	Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)IBA 05/2007 - 07/2006
2	Protein Isoforms (Isoforms)IBA 01/2006 - 08/2004
1	Glutamine (L-Glutamine)FDA Link 10/2023
1	ProdrugsIBA 10/2023
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2023
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2023
1	PlatinumIBA 01/2023
1	InterferonsIBA 01/2023
1	Immune Checkpoint ProteinsIBA 01/2023
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 08/2022
1	Long Noncoding RNAIBA 08/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	butyrylcarnitineIBA 11/2021
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 11/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	TESIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Circulating Tumor DNAIBA 01/2019
1	Genetic Markers (Genetic Marker)IBA 01/2019
1	Bevacizumab (Avastin)FDA Link 01/2019
1	Adenosine Monophosphate (AMP)IBA 01/2019
1	palbociclibIBA 12/2018
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2018
1	Drug CombinationsIBA 10/2018
1	tyrosine receptor (receptor, tyrosine)IBA 10/2018

Therapy/Procedure

30	Therapeutics 01/2023 - 08/2004
20	Drug Therapy (Chemotherapy) 07/2023 - 06/2006
8	Radiotherapy 10/2017 - 06/2006
3	Precision Medicine 01/2021 - 01/2015
3	Lab-On-A-Chip Devices 12/2019 - 12/2014
2	Immunotherapy 01/2021 - 06/2006
2	Chemoradiotherapy 10/2017 - 01/2016